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The reason this combination is referred to as “California rocket fuel” is due to the its higher than average potency and efficacy.Rockets blast off with extreme speed, and in many cases, people given this particular combination notice a rapid improvement in their depressive symptoms. to treat depression in 1996 and some comparison studies go as far as to suggest that it has the single highest efficacy of any antidepressant on the market.

remeron more sedating at lower doses-83

Since mirtazapine is sedating mainly because it is an antihistamine, possibly you could also get better results from the milder kind of over the counter or prescription antihistamine sleep aids, some of which also have shorter half lives than mirtazapine.

As you have discovered, mirtazapine is a very dirty drug (does lots of things you don't want) and there are other much cleaner and more targeted antihistamines, for example. I do take 7.5mg (half a pill) and it still dulls me out for the whole day.

In some cases the drugs have synergistic effects which results in amplification of the antidepressant response.

One such combination that has been proven effective at treating the most severe cases of depression is referred to as “California rocket fuel.” California rocket fuel is a slang term created by the psychiatric community (and some medical professionals) that refers to a combined treatment with .

Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.