Nonsedating


Once daily administration of desloratadine rapidly reduces the nasal and nonnasal symptoms of seasonal allergic rhinitis, including congestion.

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Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).

Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.

The objectives of this study were to: (i) compare electrocardiographic, monophasic action potential, and arrhythmogenic effects of sedating and nonsedating H1-receptor antagonists, and (ii) identify correlates of drug-induced torsades de pointes in an isolated ventricle model.

Further measures are optimising the treatment of other predisposing diseases and the nutritional status, appropriate analgesic drug therapy in patients with postoperative pain during breathing, prefering nonsedative analgesic drugs, early mobilization, and withdrawal or reduction of immunsuppressive drugs in the preoperative and postoperative setting if not contraindicated.

Because each patient can react differently, individuals should determine how they react to a non-sedating antihistamine before driving, taking important tests or operating dangerous machinery.