Homozygous carriers of this mutation are resistant to M-tropic strains of HIV-1 infection.
Received date: June 24, 2016; Accepted date: July 07, 2016; Published date: July 14, 2016 Citation: Admas A (2016) The Frequency and Effects of CCR5 Delta 32 Allele in Gondar Population. doi: 10.4172/2168-9547.1000168 Copyright: © 2016 Admas A.
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Methods: In this experiment, 530 normal individuals from healthy Iranian population and 40 HIV-infected samples from Western Clinic of Tehran were examined for32 in CCR5 gene using polymerase chain reaction (PCR) techniques followed by agarose gel electrophoresis.
Results: Allele frequencies of the CCR532 in normal individuals were calculated to be 1.1% for heterozygous genotype and 0.19% for homozygous genotype.
A 32bp deletion (32) in this gene is believed to be associated with resistance to infection and delay disease progression.